EFFEXOR XR is an extended-release capsule for oral administration that contains venlafaxine hydrochloride, a structurally novel antidepressant.
The usual recommended dose of Effexor for SAD is 75 mg daily. Some doctors begin at half of this dose for about a week then go up to the usual. In people in whom there is not an optimal response, the dose may go up as high as 225 mg daily.
Venlafaxine hydrochloride is a white to off-white crystalline solid with a solubility of 572 mg/mL in water (adjusted to ionic strength of 0.2 M with sodium chloride). Its octanol:water (0.2 M sodium chloride) partition coefficient is 0.43.
EFFEXOR XR is formulated as an extended-release capsule for once-a-day oral administration. Drug release is controlled by diffusion through the coating membrane on the spheroids and is not pH dependent. Capsules contain venlafaxine hydrochloride equivalent to 37.5 mg, 75 mg, or 150 mg venlafaxine. Inactive ingredients consist of cellulose, ethylcellulose, gelatin, hypromellose, iron oxide, and titanium dioxide.
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