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NASONEX Nasal Spray (the active component is Mometasone furoate monohydrate) is a corticosteroid demonstrating potent anti-inflammatory properties. The precise mechanism of corticosteroid action on allergic rhinitis is not known. Corticosteroids have been shown to have a wide range of effects on multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, and lymphocytes) and mediators (e.g., histamine, eicosanoids, leukotrienes, and cytokines) involved in inflammation.
NASONEX Nasal Spray is an anti-inflammatory corticosteroid having the chemical name, 9,21-Dichloro-11, 17-dihydroxy-16 -methylpregna-1,4-diene-3,20-dione 17-( 2 furoate) monohydrate.
Mometasone furoate monohydrate is a white powder, with an empirical formula of C27H30Cl2O6 H2O, and a molecular weight of 539.45. It is practically insoluble in water; slightly soluble in methanol, ethanol, and isopropanol; soluble in acetone and chloroform; and freely soluble in tetrahydrofuran. The pH is between 4.3 and 4.9.
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