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Purchase Protopic online

Protopic medicine online

Protopic without prescription

Protopic is an immunosuppressant. It works by decreasing your body's immune system. Protopic topical (for the skin) is used to treat severe atopic dermatitis (ezcema).
WedPharmacy
Product name : Protopic
Dosage : 10g/0.03%, 30g/0.1%
Quantity : 1, 2 tubes
Min price : $25.00 per tube
Delivery : Worldwide
Shipping methods : Standard International Airmail (10-21 days)
Shipping cost : $ 9.95
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Protopic Ointment 10g/0.03% + FREE BONUS PILLS
packagepriceper itemorder
2 tubes $50.00 $25.00 buy now
Protopic Ointment 30g/0.1% + FREE BONUS PILLS
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2 tubes $380.00 $190.00 buy now
Protopic - Mechanism of Action. The mechanism of action of tacrolimus in atopic dermatitis is not known. While the following have been observed, the clinical significance of these observations in atopic dermatitis is not known. It has been demonstrated that tacrolimus inhibits T-lymphocyte activation by first binding to an intracellular protein, FKBP-12. A complex of tacrolimus-FKBP-12, calcium, calmodulin, and calcineurin is then formed and the phosphatase activity of calcineurin is inhibited. This effect has been shown to prevent the dephosphorylation and translocation of nuclear factor of activated T-cells (NF-AT), a nuclear component thought to initiate gene transcription for the formation of lymphokines (such as interleukin-2, gamma interferon). Tacrolimus also inhibits the transcription for genes which encode IL-3, IL-4, IL-5, GM-CSF, and TNF-α, all of which are involved in the early stages of T-cell activation. Additionally, tacrolimus has been shown to inhibit the release of pre-formed mediators from skin mast cells and basophils, and to down regulate the expression of FcεRI on Langerhans cells.

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